〒305-0851 茨城県つくば市大わし1-2 独立行政法人 農業生物資源研究所内ラボ
Recombinant protein production in plant systems can be promising technology in terms of cost benefit and safety. PrevenTec, Inc. is developing a cytokine production by recombinant rice. There is no contamination of animal components and bacterial components when the protein was produced in rice seed. PrevenTec, Inc. would like to provide a high quality recombinant proteins for client.
We developed a recombinant rice which express a cytokine. Then we developed the procedure for extraction and purification of a cytokine from rice seed. The cytokines purified from rice seed have high activity upon susceptible cells and contain less than 10-5EU/μg of endotoxin.
PrevenTec, Inc. have focused on the cytokine adjuvant for infectious diseases, allergic & autoimmune diseases and cancer.
We are looking for a partner for collaboration
and/or alliance to develop an vaccine. We are also looking for a client who is
interested in biosimilar,
cell culture additive and cosmetic ingredient.
IFNα2a, 2b, GM-CSF ; Those are candidate of biosimilar or adjuvant
for infectious disease and cancer vaccine.
IL-10, TGF-β, IL-4 ; Those are adjuvant of mucosal tolerance for
allergic and autoimmune diseases.
Acquired immunity is required for activation of the innate immune systems. Adjuvant as a substance that activate dendritic cells serve as a link between the innate and aquired immune systems.
Since recombinant protein antigens show low immunogenicity, recombinant protein vaccine requires an adjuvant. However there is not many available adjuvants. The utilization of the cytokine adjuvant could be improved by edure.The rice produced cytokine is a good candidate as anadjuvant for topical administrationon mucosal and transdermal surface.